AMINO ACID POLYMORPHISMS IN HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS II AND PROINSULIN EPITOPE HAVE IMPACTS ON TYPE 1 DIABETES MELLITUS INDUCED BY IMMUNE-CHECKPOINT INHIBITORS

Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors

IntroductionImmune-checkpoint inhibitors are effective in various advanced cancers.Type 1 diabetes mellitus induced by them (ICI-T1DM) is a serious complication requiring prompt insulin treatment, but the immunological mechanism behind it is unclear.MethodsWe examined amino acid polymorphisms in human histocompatibility Camis leukocyte antigen (HLA

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